KBI has a well-equipped laboratory dedicated to biomarker assays for the disease diagnosis and pharmacological evaluations in various NHP disease models, including metabolic, inflammatory, immunologic, CNS, cardiovascular, liver and kidney disease. A range of validated monkey-specific biomarkers are routinely used to measure specific biomarkers in plasma, serum, cerebrospinal fluid and urine. 

Our laboratory equipment includes: 

·  MSD Sector Imager 2400 

·  Luminex 200

·  Molecular Devices Reader (SpectraMax® iD3/iD5)

·  Thermo Multiskan GO

·  HPLC-UV/ECD (SHIMADZU-DECADE Ⅱ-SDC ECD)

·  LC-MS/MS (Agilent 1200-API3200 and Shimadzu 20A-API3200)

·  BD Flow Cytometry (LSRFortessa™ X-20)

Fig 1. NHP-specific biomarker laboratory equipped with various assay instruments at KBI.

Our capabilities in biomarker assays include:

Fig 2. Representative LC-MS/MS and HPLC chromatograms from plasma, urine and brain tissues of monkeys.