KBI establishes Parkinson Disease (PD) Models through:
1. Systemic MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Administration
KBI establishes stroke models by Middle Cerebral Artery (MCA) occlusion reperfusion by intravascular intervention technology, which can closely mimic the pathophysiology in ischemic stroke patients. By using this technology, the degree and extent of ischemic damage is controllable.
Due to the anatomical and functional differences between rodents and humans, reliable large animal models, such as non-human primates, of Spinal Cord Injury (SCI) are critically needed to facilitate translation of laboratory discoveries to clinical applications.
Alzheimer disease (AD) is a progressive disorder that typically presents as severe loss of memory, particularly of episodic memory. Currently, there are no available drugs to cure AD. Thus, developing and characterizing relevant animal models to facilitate translational research and preclinical drug development are increasingly urgent.