Age-related macular degeneration (AMD) is a common eye disease that leads to the central vision loss among people age over 50. There are two types of AMD: dry (atrophic) and wet (neovascular or exudative). Most AMD starts as the dry type. Ten to 20% of AMD patients will progress to wet AMD.

AMD models at KBI are:

·  Spontaneous in aged monkeys

·  Blue light-induced (dry AMD)

·  Argon laser-induced CNV (wet AMD)

The blood vessel leakage and retinal neovascularization are confirmed using fluorescein angiography (FA) and optical coherence tomography (OCT). Retinal lesions of CNV are determined and characterized using imaging analysis of FA.