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Disease Models

Age-related Macular Degeneration

Kunming, China, August 18, 2023

Age-related macular degeneration (AMD) is a common eye disease that leads to the central vision loss among people age over 50 years. There are two types of AMD: dry (atrophic) and wet (neovascular or exudative). Ten to 20% of AMD patients will progress to wet AMD.

AMD models available at KBI include:

·  Spontaneous AMD in aged monkeys

·  Blue light-induced (dry AMD)

·  Argon laser-induced CNV (wet AMD)

·  DL-2-aminoadipic acid (DL-AAA) induced macular edema and vascular leakage

As shown in the figures below, the vascular leakage and retinal neovascularization are confirmed using fundus photography (FP), fluorescein angiography (FA) and optical coherence tomography (OCT). Retinal lesions of choroidal neovascularization (CNV) are determined and characterized using imaging analysis of FA and OCT.


Fig 1. Representative images of spontaneous AMD (dry AMD) in aged cynomolgus monkeys. 


Fig 2. Representative images of blue light-induced AMD (dry AMD) in cynomolgus monkeys.


Fig 3. Representative images of laser-induced choroidal neovascularization (CNV, wet AMD) in cynomolgus monkeys.

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