KBI has two monkey models of inflammatory bowel disease (IBD) available for the evolution of therapeutic agents and the investigation of the pathogenic mechanisms. One model is spontaneously developed where KBI utilizes colonoscopy to identify ulcerative colitis with characteristic clinical signs of chronic or recurrent IBD.

Spontaneous IBD is identified by routinely screening of our large monkey cohort according to the following criteria:

·  chronic diarrhea for more than 6 months

·  chronic body weight loss in more than 3 months

·  fecal examination to exclude parasite infestation

·  endoscopy examination to confirm multiple and continuous colonic ulcers

·  endoscopic findings of colonic ulcers during the 2-month follow-up

·  biopsy findings of colonic crypts and mucosal damage

·  IHC staining for TNF-α from biopsy specimen from colon.

Fig 1. Spontaneous inflammatory bowel disease (IBD) in cyno monkeys at KBI.

Additionally, KBI has established DSS-induced stable model of chronic IBD with a well-defined protocol with similar assessment criteria as described above.

Fig 2. Representative images of DSS-induced IBD in cyno monkeys at KBI.