Spinal Cord Injury (SCI) are critically needed to facilitate translation of laboratory discoveries to clinical applications. KBI has designed a spinal cord impactor and operating procedures specific for producing a SCI model in monkeys to successfully evaluate the therapeutics for the treatment of SCI models.
The outcome measures for the evaluation of therapeutic efficacy include:
· behavioral changes
· lesion volume from H&E staining
· special biomarkers
· immunohistochemistry staining
Fig 1. Spontaneous motor activity (Left) and H&E staining of spinal cord injury (Right). Multiple cross sections were stained with H&E at the study end (X40) with the injury areas indicated by white arrow(s).
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