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Disease Models

Spinal Cord Injury Model

Kunming, China, August 10, 2023

Spinal Cord Injury (SCI) are critically needed to facilitate translation of laboratory discoveries to clinical applications. KBI has designed a spinal cord impactor and operating procedures specific for producing a SCI model in monkeys to successfully evaluate the therapeutics for the treatment of SCI models. 

The outcome measures for the evaluation of therapeutic efficacy include:

·  behavioral changes

·  lesion volume from H&E staining

·  special biomarkers 

·  immunohistochemistry staining


Fig 1. Spontaneous motor activity (Left) and H&E staining of spinal cord injury (Right). Multiple cross sections were stained with H&E at the study end (X40) with the injury areas indicated by white arrow(s).

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