Myocardial infarction and heart failure are rated as the leading cause of mortality worldwide. Myocardial ischemia/reperfusion injury has gained recognition as a clinically relevant model for myocardial infarction studies. For this reason, the cynomolgus monkey model of myocardial ischemia/reperfusion provides translational value that is vital to investigate the acute and chronic pathophysiological processes in myocardial infarction, as well as, to develop, evaluate, and optimize available and prospective therapeutic interventions.
At KBI, the transient Acute Myocardial Injury (AMI) is induced in the cynomolgus monkey by left anterior descending (LAD) ligation-reperfusion. The model correlates well with the post-AMI induction ECG changes of ST elevation myocardial infarction (STEMI), the time-course changes in cardiac enzymes (CK and LDH), as well as, the consequent gross morphological and histopathological changes.
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