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Disease Models

Heart Infarction and Reperfusion Model

Kunming, China, July 20, 2023

Myocardial infarction and heart failure are leading causes of the mortality worldwide. The NHP models of myocardial ischemia/reperfusion injury are very unique for the evaluation of new therapeutics (particularly protein products and gene therapies) to clinical application devoid of inter-species variations.

KBI has various models of heart infarction and ischemic-reperfusion by blocking the left anterior descending (LAD) artery either permanently or temporarily (e.g. for 2-4 


The cardiac injury of heart infarction and ischemic reperfusion can be monitored by the following techniques:

·  ST elevation (STEMI) in ECG, 

·  serum levels of creatine kinase (CK), creatine kinase iso-enzymes (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin T (cTnT), 

·  ultrasound (echocardiography) 

·  cardiac MRI 

·  terminal gross morphology and histopathology. 

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Fig 1. Characteristics of myocardial infarction over time in monkeys after acute myocardial infarction (AMI) by ligating of the left anterior descending artery. 

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Fig 2. Changes in serum enzymes, echocardiography and cardiac MRI over time post-ischemia (4 hrs) reperfusion in monkeys.

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