KBI has more than 1,000 monkeys at stages of pre-diabetes, overt diabetes and diabetes with complications for the evaluation of new drugs:  

·  Pre-diabetes (hyperinsulinemia, impaired glucose tolerance, insulin resistance)  

·  Type 2 diabetes with hyperinsulinemia and hypoinsulinemia 

·  Diabetic nephropathy

·  Diabetic retinopathy

·  Diabetic Neuropathy

A full array of comprehensive tools are well established for the detailed characterization at various stages including: 

·  Clinical chemistry for metabolic profiling

·  Oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT) and insulin tolerance test (ITT)

·  Oral lipid tolerance test (OLTT) and meal tolerance test (MTT)

·  Graded glucose infusion (GGI)

·  Hyperinsulinemic-euglycemic clamp

·  GI-bypass and gastric emptying

The KBI proprietary high-fat diets formulated to replicate the Western-type diet in humans have been used to successfully develop metabolic syndrome, dyslipidemia, 

diabetes and associated co-morbidities in monkeys.