KBI has a cohort of monkeys with spontaneous hypertension identified by the measurement of blood pressure (BP) with High Definition Oscillometry (HDO). Through the screening of a large cohort of monkeys, KBI has established the normal range of BP and diagnostic values for hypertension in monkeys:
Myocardial infarction and heart failure are leading causes of the mortality worldwide. The NHP models of myocardial ischemia/reperfusion injury are very unique for the evaluation of new therapeutics (particularly protein products and gene therapies) to clinical application devoid of inter-species variations.
KBI has established a step-wise screening system with the use of clinical chemistry, blood biomarkers, echocardiogram and myocardial MRI to characterize different types of heart failure (HF) with a large body of database. We have produced models of heart failure with either reduced ejection fraction (HFrEF, or systolic failure) or preserved ejection fraction (HFpEF, diastolic failure) from more than 1,000 prolonged HFD monkeys (Fig 1).