Obesity is major risk factor underlying diabetes, cardiovascular disease (CVD), chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH), together they impose serious health problems worldwide. Kunming Biomed International (KBI) has established both spontaneously obesity and high fat diet (HFD)-induced obesity in a large cohort of non-human primate (NHP) cynomolgus monkeys. These two different types of obesity models closely resemble the etiologies (hyperphagia and overconsumption of fat) and phenotypes (diagram below) as seen in humans. As the phenotypes (e.g., adipose tissue browning) and lipid metabolism (e.g., lipoproteins) in NHPs resembles those in humans with not or little species difference, these obesity models can provide more reliable and accurate prediction for the effects of a new drug in future clinical use.